Multiparametric ultrasound imaging of the respiratory and locomotor muscles

Last updated on Jan 15, 2021

We are developing new approaches based on multiparametric ultrasound for the characterization of muscle structure and function. This project includes the use of ultrafast plane wave imaging, strain imaging, and shear wave elastography.

Within this topic, the RESPIMYO project focuses on the application of multiparametric ultrasound in the diaphragm to propose specific and non-invasive alternatives for the evaluation of diaphragmatic dysfunction associated with neuromuscular disorders, respiratory diseases, and those induced by mechanical ventilation in the intensive care unit.

Current research is carried out in collaboration with the BIOMAPS laboratory (Université Paris-Sud - CEA), the NMR laboratory of the Institute of Myology, the R3S (Respiration, Reanimation, Rehabilitation, Sleep) department of the APHP-SU, and the Radboudumc University Medical Centre in Holland.

See related works and publications below.

multiparametric ultrasound imaging diaphragm internal
Damien Bachasson
Damien Bachasson
PT, PhD, Researcher

science, muscle, physiology, exercise, diaphragm, rehabilitation, bioengineering enthusiast.

Related

Publications

Non-invasive assessment of skeletal muscle fibrosis in mice using nuclear magnetic resonance imaging and ultrasound shear wave elastography
Fibrosis is a key pathological feature in muscle disorders, but its quantification mainly relies on histological and biochemical …
Aurea B. Martins-Bach, Damien Bachasson, Ericky C. A. Araujo, Lucas Soustelle, Paulo Loureiro de Sousa, Yves Fromes, Pierre G. Carlier
PDF Cite Project DOI
Ultrasound shear wave elastography for assessing diaphragm function in mechanically ventilated patients: a breath-by-breath analysis
BACKGROUND: Diaphragm dysfunction is highly prevalent in mechanically ventilated patients. Recent work showed that changes in diaphragm …
Q. Fosse, T. Poulard, M. C. Nierat, S. Virolle, E. Morawiec, J. Y. Hogrel, T. Similowski, A. Demoule, J. L. Gennisson, D. Bachasson, M. Dres
PDF Cite Project DOI
Ultrafast ultrasound coupled with cervical magnetic stimulation for non-invasive and non-volitional assessment of diaphragm contractility
KEY POINTS: Twitch transdiaphragmatic pressure elicited by cervical magnetic stimulation of the phrenic nerves is a fully …
T. Poulard, M. Dres, M. C. Nierat, I. Rivals, J. Y. Hogrel, T. Similowski, J. L. Gennisson, D. Bachasson
PDF Cite Project DOI
Relationship between diaphragm thickening fraction and transdiaphragmatic pressure in healthy and mechanically ventilated patients: a breath by breath analysis
T. Poulard, Q. Fosse, J. L. Gennisson, M. C. Nierat, J. Y. Hogrel, T. Similowski, A. Demoule, D. Bachasson, M. Dres
PDF Cite Project DOI
Shear wave elastography for assessing diaphragm activity in mechanically ventilated patients
Q. Fosse, T. Poulard, J. Hogrel, J. Gennisson, T. Similowski, A. Demoule, M. Nierat, D. Bachasson, M. Dres
PDF Cite Project DOI
Diaphragm thickening fraction versus transdiaphragmatic pressure in healthy subjects and ventilated patients: a breath-by-breath analysis
Introduction: Diaphragm thickening fraction (TFdi) measured by ultrasound is widely used to evaluate diaphragm function to optimize …
Thomas Poulard, Quentin Fossé, Jean-Luc Gennisson, Marie-Cécile Nierat, Jean-Yves Hogrel, Thomas Similowski, Alexandre Demoule, Damien Bachasson, Martin Dres
Cite Project DOI
Method, device and apparatus for measuring diaphragmatic functional parameters
Method for measuring diaphragmatic functional parameters, comprising: • a) stimulation of the diaphragm to generate a movement of the …
D. Bachasson, J. Hogrel, M. Dres, J. Gennisson, T. Similowski
PDF Cite Project DOI
Ultrasound shear wave elastography for non-invasive assessment of diaphragm activity in mechanically ventilated patients
Introduction: Mechanical ventilation is a life-saving treatment that is however associated with diaphragm dysfunction. The optimal …
Quentin Fossé, Thomas Poulard, Jean-Yves Hogrel, Jean-Luc Gennisson, Thomas Similowski, Alexandre Demoule, Marie-Cécile Nierat, Damien Bachasson, Martin Dres
Cite Project DOI
Diaphragm shear modulus reflects transdiaphragmatic pressure during isovolumetric inspiratory efforts and ventilation against inspiratory loading
The reference method for the assessment of diaphragm function relies on the measurement of transdiaphragmatic pressure (Pdi). Local …
D. Bachasson, M. Dres, M. C. Nierat, J. L. Gennisson, J. Y. Hogrel, J. Doorduin, T. Similowski
PDF Cite Project DOI
Ultrasound shear wave elastography for assessing diaphragm function within the intensive care unit
T. Poulard, Q. Fosse, J. Hogrel, M. Nierat, T. Similowski, M. Dres, D. Bachasson, J. Gennisson
PDF Cite Project DOI
Ultrafast Ultrasound Imaging Grants alternate Methods for Assessing Diaphragm Function
D. Bachasson, M. Dres, M. Nierat, J. Doorduin, J. Gennisson, J. Hogrel, T. Similowski
PDF Cite Project DOI
Changes in diaphragm stiffness assessed with ultrasound shear wave elastography reflect changes in transdiaphragmatic pressure
Background: Transdiaphragmatic pressure (Pdi) is the gold standard for the assessment diaphragm function. However, it is an indirect …
Damien Bachasson, Martin Dres, Marie-Cécile Nierat, Jonne Doorduin, Jean-Luc Gennisson, Jean-Yves Hogrel, Thomas Similowski
Cite Project DOI
Muscle Shear Wave Elastography in Inclusion Body Myositis: Feasibility, Reliability and Relationships with Muscle Impairments
Degenerative muscle changes may be associated with changes in muscle mechanical properties. Shear wave elastography (SWE) allows direct …
D. Bachasson, G. J. R. Dubois, Y. Allenbach, O. Benveniste, J. Y. Hogrel
PDF Cite Project DOI
Muscle alterations in sporadic inclusion body myositis assessed using quantitative nuclear magnetic resonance imaging and spectroscopy, ultrasound shear-wave elastography, and relationships with muscle function
D. Bachasson, H. Reyngoudt, S. Turk, .. Benveniste, J. Hogrel, P. Carlier
PDF Cite Project DOI
Lower muscle stiffness assessed with supersonic shear imaging is associated with more severe muscle impairments in patients with sporadic inclusion body myositis
Supersonic shear imaging (SSI) is a recently developed technique for noninvasive assessment of tissue stiffness. In muscle, mechanical …
D. Bachasson, G. Dubois, O. Benveniste, J. Hogrel
PDF Cite Project DOI